Process for racemization of n-acylamino acids by means of transition metal catalysts

US6437175B1 · kind B1 · utility

Assignee

• Aventis Research & Technologies GmbH & Co. · DE

Inventors

• Thomas Riermeier · Wemding, DE
• Matthias Beller · Ostseebad Nienhagen, DE
• Daniel Schichl · Garching bei München, DE
• Martin Hateley · Aschaffenburg, DE

Key dates

• Filing date: Mar 12, 2001
• Grant date: Aug 20, 2002
• Expiry date: Mar 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C231/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the racemization of N-acylamino acids of the formula (I)R—CH(NR1COR2)CO2H   (I) in which, in a solvent, an enantiomerically enriched mixture or an enantiomerically pure compound of the formula (I) is reacted in the presence of a transition metal salt, transition metal complex or transition metal complex salt or of a mixture thereof comprising at least one element from the group consisting of Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt, preferably at a temperature of 10-150° C.