&agr;-hydroxy, -amino, and halo derivatives of &bgr;-sulfonyl hydroxamic acids as matrix metallopropteinases inhibitors

US6437177B1 · kind B1 · utility

Inventors

• Martha A. Warpehoski · Portage, US
• Mark A. Mitchell · Kalamazoo, US
• Donald E. Harper · Plainwell, US
• Linda Louise Maggiora · Kalamazoo, US

Key dates

• Filing date: Nov 20, 1998
• Grant date: Aug 20, 2002
• Expiry date: Nov 20, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, —(CH2)h—C3-8 cycloalkyl, substituted and unsubstituted —(CH2)h-aryl, substituted and unsubstituted —(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted —(CH2)h—C3-8 cycloalkyl, substituted and unsubstituted —(CH2)h—C3-8 cycloalkenyl, substituted and unsubstituted —(CH2)h-aryl, substituted and unsubstituted —(CH2)h-heterocyclic ring, substituted and unsubstituted —(CH2)i—X—R4 (X is —O—, —S(═O)j—, —NR7—, —S(═O)2NR8—, or —C(═O)—), and —(CH2)iCHR5R6.The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.