1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol and its uses
US6440953B1 · kind B1 · utility
16Cited by
7References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 11, 2001 |
| Grant date | Aug 27, 2002 |
| Priority date | — |
| Expiry date | Jun 11, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C401/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses 1&agr;-hydroxy-2-methylene-19-nor-homopregnacalciferol and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anticancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat immune disorders in humans as well as renal osteodystrophy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.