Reverse-turn mimetics and methods relating thereto
US6440955B1 · kind B1 · utility
21Cited by
4References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 4, 2001 |
| Grant date | Aug 27, 2002 |
| Priority date | — |
| Expiry date | Sep 4, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70546
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R1, R2, R2a, R3, R3a and R4 are as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.