Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
US6440989B2 · kind B2 · utility
5Cited by
17References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 13, 2001 |
| Grant date | Aug 27, 2002 |
| Priority date | — |
| Expiry date | Feb 13, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel phenyl-substituted tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.