Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof

US6440992B1 · kind B1 · utility

Assignee

• 3M INNOVATIVE PROPERTIES COMPANY · US

Inventors

• John F. Gerster · Woodbury, US
• Kyle J. Lindstrom · Houlton, US
• Gregory J. Marszalek · Windom, US
• Bryon A. Merrill · River Falls, US
• John Mickelson · Mattawan, US
• Michael J. Rice · Oakdale, US

Key dates

• Filing date: Sep 24, 2001
• Grant date: Aug 27, 2002
• Expiry date: Sep 24, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D517/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.