Sulphonyloxazolamines as therapeutic active ingredients

US6441013B1 · kind B1 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Hartmut Greiner · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Henning Bottcher · Darmstadt, DE
• Gerhard Barnickel · Darmstadt, DE
• Bertram Cezanne · Mörfelden, DE

Key dates

• Filing date: Jun 14, 2001
• Grant date: Aug 27, 2002
• Expiry date: Jun 14, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to sulphonylexazolamines of general formula (I), wherein R1, R2 represent independently from each other H, A, —(CH2)n—Ar or alkenyl with 2-6 C atoms, R1 and R2 together also represent a mononuclear saturated heterocycle with 1-2 N, O and/or S atoms, Z is H, A, CF3, NO2, Hal, OH, OA, NH2, NHA or NH2. A represents alkyl with 1-6 C atoms, Ar is Z-monosubstituted or Z-disubstituted phenyl, Hal is F, Cl, Br, or L n is 1 or 2 of the physiologically acceptable salts or solvates thereof. Said sulphonyloxazolamines are used as therapeutic active ingredients. The invention also relates to the use of sulphonyloxazolamines as therapeutic active ingredients and/or to the production of pharmaceutical preparations to combat diseases of the central nervous system. The invention further relates to a pharmaceutical preparation and the production thereof.