Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use

US6441022B1 · kind B1 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Wendelin Frick · Bad Camberg, DE
• Alfons Enhsen · Lennestadt, DE
• Heiner Glombik · Hofheim, DE
• Hubert Heuer · Frankfurt am Main, DE

Key dates

• Filing date: Feb 2, 2001
• Grant date: Aug 27, 2002
• Expiry date: Feb 2, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.