Inhibitors of glycogen synthase kinase-3 and methods for identifying and using the same
US6441053B1 · kind B1 · utility
23Cited by
4References
1Claims
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Key dates
| Filing date | Jun 8, 1999 |
| Grant date | Aug 27, 2002 |
| Priority date | — |
| Expiry date | Jun 8, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of identifying inhibitors of glycogen synthase kinase-3 is provided. The method comprises providing a mixture comprising GSK-3, a phosphate source, and a GSK-3 substrate, incubating the mixture in the presence or absence of a test compound, and assessing the activity of GSK-3 in the mixture. A reduction of GSK-3 activity following incubation of the mixture in the presence of the test compound is an indication that the test compound is an inhibitor of GSK-3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.