Patent · US Expired

Synthetic peptides, antibodies against them and their use

US6441141B1 · kind B1 · utility

0Cited by

10References

11Claims

0Family size

Assignee

Dade Behring Marburg GmbH · DE

Inventors

Michael Kraus · Ehrenkirchen, DE
Werner Stuber · Lahntal, DE

Key dates

Filing date	Sep 29, 1999
Grant date	Aug 27, 2002
Priority date	—
Expiry date	Sep 29, 2019

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S930/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to the generation of antibodies which preferentially bind to fibrinogen fragments E1, E2 and E3, but exhibit little or no cross-reactivity against fibrin monomer and fibrinogen. Thus, the invention provides synthetic peptides containing defined amino acid sequences corresponding to the carboxy terminal regions of the E fragments which arise as a result of plasmin cleavage of fibrin and fibrinogen. The synthetic peptides may be synthesized chemically, or through genetic manipulations, and may contain additional amino acid sequences which are not contiguous with the defined E fragment sequences.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.