Podophyllotoxin dimer as DNA topoisomerase II inhibitors, and a process for the preparation therefore
US6441198B1 · kind B1 · utility
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9Claims
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Key dates
| Filing date | Dec 22, 2000 |
| Grant date | Aug 27, 2002 |
| Priority date | — |
| Expiry date | Dec 22, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention discloses novel podophyllotoxin dimers having structural formula I wherein R is H or CH3 and Z is aryl or subsituted aryl compound selected form the group counting of phenylene, naphthalene, p-terpbhnyl, dimethoxy benzidine and diphenyl ether and a process for the preparation of said novel podophyllotoxin dimers. The new podophyllotoxin dimers, pawculaty 4-arylamino derivatives of the podophyllotoxin dimers of the present invention as useful as potent inhibitors of DNA-topoisomerase II and are also useful as antitumour agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.