Selective nitrogen functionalization of organic compounds
US6441232B1 · kind B1 · utility
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10Claims
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Key dates
| Filing date | Jan 1, 2002 |
| Grant date | Aug 27, 2002 |
| Priority date | — |
| Expiry date | Jan 1, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a method of selectively replacing a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom in an organic compound by a carbon-nitrogen bond, the method comprising reacting the compound with a fluorinating agent in a solvent reaction medium comprising a nitrile compound and providing a Lewis acid whereby the carbon-hydrogen bond is replaced by a carbon-nitrogen bond. Advantageously, the reaction may be performed in one stage and/or in one vessel. Advantageously, the method may be carried out at or just below ambient or room temperature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.