Production of &bgr;-glucan-mannan preparations by autolysis of cells under certain pH, temperature and time conditions

US6444448B1 · kind B1 · utility

Assignee

• Carlton and United Breweries Limited · AU

Inventors

• Ragini Wheatcroft · Melbourne, AU
• Joseph Kulandai · Melbourne, AU
• Robert Gilbert · South River, US
• Keith James Sime · Melbourne, AU
• Craig Gordon Smith · Melbourne, AU
• Willem Hendrik Langeris · Melbourne, AU

Key dates

• Filing date: Jun 24, 1998
• Grant date: Sep 3, 2002
• Expiry date: Jun 24, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P19/14
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

There is provided a method of production of an immunostimulatory &bgr;-glucan-mannan preparation, comprising the step of autolysis of cells of a microorganism at a pH of 5 to 6 and a temperature of 35 to 60° C. for 6 to 48 hours, and separating solid material roam the autolysed product.The &bgr;-glucan-mannan preparation may be incorporated as a food component or be used as a pharmaceutical for treatment of conditions such as immuno-suppression, hypercholesterolaemia, hypoglycaemia and heavy metal excretion.