Fatty acid-acylated insulin analogs
US6444641B1 · kind B1 · utility
49Cited by
15References
39Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 7, 2000 |
| Grant date | Sep 3, 2002 |
| Priority date | — |
| Expiry date | Jul 7, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Fatty acid-acylated insulin analogs are soluble at moderately acidic pH and provide long-acting basal control of glucose levels. In such a molecule, the insulin analog portion comprises an insulin A-chain, or an analog thereof, properly cross-linked to an analog of the insulin B-chain, wherein the &egr;-amino group of a Lys residue at either positions 28 or 29 of the B-chain analog is acylated with a fatty acid. The insulin analog portion of the molecules comprises an A-chain of insulin, or an analog thereof, with an optional Arg at position 0, properly cross-linked to a B-chain analog that includes Arg at positions 31 and 32.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.