Substituted pyrimidine compounds and the use thereof

US6444674B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Beate Hellendahl · Mannheim, DE
• Annegret Lansky · Darmstadt, DE
• Rainer Munschauer · Shrewsbury, US
• Siegfried Bialojan · Oftersheim, DE
• Liliane Unger · Ludwigshafen, DE
• Hans-Jurgen Teschendorf · Dudenhofen, DE
• Karsten Wicke · Ludwigshafen, DE
• Karla Drescher · Ludwigshafen, DE

Key dates

• Filing date: Aug 29, 2001
• Grant date: Sep 3, 2002
• Expiry date: Aug 29, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of pyrimidine compounds of the following formula: where R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.