Method of preparing form II crystals of clarithromycin
US6444796B1 · kind B1 · utility
17Cited by
2References
9Claims
0Family size
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Key dates
| Filing date | Oct 20, 2000 |
| Grant date | Sep 3, 2002 |
| Priority date | — |
| Expiry date | Oct 20, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Pure Form II crystals of clarithromycin can be prepared by a simple, high-yield process comprising the steps of treating crude clarithromycin or different crystal forms of clarithromycin with formic acid in an organic solvent to obtain crystalline clarithromycin formate and neutralizing the clarithromycin formate with a base in a mixture of water and a water-miscible organic solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.