Chimeras of sulfur-linked oligonucleotide analogs and DNA and RNA
US6444798B1 · kind B1 · utility
Inventor
Key dates
| Filing date | May 13, 1996 |
| Grant date | Sep 3, 2002 |
| Priority date | — |
| Expiry date | May 13, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention dicloses compositions of matter that are oligonucleotide analogs containing one or more improvements, where the improvement consists of replacing one or more of the phosphodiester linking units (—O—PO2−—O—) by a dimethylene sulfide (—CH2—S—CH2—), sulfoxide (—CH2—SO—CH2—), or sulfone linking unit (—CH2—SO2—CH2—). This linkage is stable to degradation both by enzymes and by alkaline hydrolysis, contains no stereogenic atoms, and confers improved stability and the ability to fold into tertiary structure upon natural oligonucleotides and their analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.