Process for the production of enantiomerically pure or optically enriched sertraline-tetralone using continuous chromatography
US6444854B1 · kind B1 · utility
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21Claims
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Key dates
| Filing date | May 1, 2001 |
| Grant date | Sep 3, 2002 |
| Priority date | — |
| Expiry date | May 1, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/79
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the production of enantiomerically pure or optically enriched sertraline-tetralone from a mixture containing two enantiomers using continuous chuomatography. The chromatography comprises a liquid mobile phase comprising at least one polar solvent and a solid chiral stationary phase comprising a derivatized polysaccharide that is selected from amylosic, cellulosic, chitosan, xylan, curdlan, and inulan class of polysaccharide.
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