Acyl CoA: cholesterol acyltransferase related nucleic acid sequences
US6444876B1 · kind B1 · utility
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32Claims
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Key dates
| Filing date | Jun 4, 1999 |
| Grant date | Sep 3, 2002 |
| Priority date | — |
| Expiry date | Jun 4, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8247
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
By this invention, novel nucleic acid sequences encoding for acyl-CoA: cholesterol acyltransferase (ACAT) related proteins are provided, wherein ACAT-like protein is active in the formation of a sterol ester and/or triacylylgycerol from a fatty acyl-CoA and sterol and/or diacylglycerol substrates. Also considered are amino acid and nucleic acid sequences obtainable from ACAT-like nucleic acid sequences and the use of such sequences to provide transgenic host cells capable of producing sterol esters and/or triacylglycerols.
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