Methods of gene therapy with a DNA sequence encoding NOS
US6447768B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1999 |
| Grant date | Sep 10, 2002 |
| Priority date | — |
| Expiry date | Dec 29, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/203
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A nucleic acid delivery vehicle for enhancing and/or inducing angiogenesis. This nucleic acid delivery vehicle includes a nucleic acid having at least one sequence coding for a protein capable of increasing nitric oxide production, and further includes a nucleic acid delivery carrier. The vehicle can be used in a method for enhancing and/or inducing angiogenesis in an individual which involves providing cells of the individual with the nucleic acid delivery vehicle. Also disclosed is a cell for producing the nucleic acid delivery vehicle for enhancing and/or inducing angiogenesis. As before, the nucleic acid delivery vehicle includes a nucleic acid having at least one sequence coding for a protein capable of increasing nitric oxide production, and further includes a nucleic acid delivery carrier wherein the nucleic acid delivery carrier includes a virus vector selected from the group of adenoviral vector and adeno-associated viral vectors, the cell comprising means for producing the virus vector in the absence of replication competent adenovirus and adeno-associated virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.