Sustained release hydrophobic bioactive PLGA microspheres

US6447796B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Noelle Christine Vook · Schaumburg, US
• Elliott Jacob · Silver Spring, US
• Jean A. Setterstrom · Silver Spring, US
• John E. Van Hamont · Clarence, US
• William Vaughan · Silver Spring, US
• Ha Duong · Montclair, US

Key dates

• Filing date: Aug 21, 1997
• Grant date: Sep 10, 2002
• Expiry date: Aug 21, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2367/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A controlled release microcapsulate pharmaceutical formulation for burst-free, sustained, programmable release of hydrophocib bioactive agent over a duration from 24 hours to 100 days comprising: and a blend of end-capped uncapped biocompatible, biodegradable poly(lactide/glycolide).