Methods for solid phase synthesis of mercapto compounds and derivatives, combinatorial libraries thereof and compositions obtained thereby
US6448058B1 · kind B1 · utility
3Cited by
4References
3Claims
0Family size
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Key dates
| Filing date | Sep 11, 1998 |
| Grant date | Sep 10, 2002 |
| Priority date | — |
| Expiry date | Sep 11, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N11/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods of preparing combinatorial libraries of mercapto (thiol) compounds them and compositions obtained therefrom are disclosed. The compounds are synthesized on a solid support. Following synthesis, the compounds are optionally cleaved from the support. One such method of synthesis involves attack of an S-protected nucleophile on a resin functionalized with a leaving group. The invention also provides for screening the mercapto compounds for bioactive compounds; in particular, for inhibitors of MMPs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.