Substituted amides, their production and their use

US6448254B1 · kind B1 · utility

Assignee

• Abbott Laboratories · US

Inventors

• Wilfried Lubisch · Mannheim, DE
• Achim Möller · Bad Kötzting, DE
• Hans-Jörg Treiber · Münstermaifeld, DE
• Monika Knopp · Ludwigshafen, DE

Key dates

• Filing date: Oct 3, 2000
• Grant date: Sep 10, 2002
• Expiry date: Oct 3, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/96
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Amides of the general formula I and their tautomeric and isomeric forms, possible enantiomeric and diastereomeric forms, as well as possible physiologically tolerable salts, in which the variables have the following meanings:R1 [sic] can be C1-C6-alkyl, phenyl, naphthyl, quinolyl, pyridyl, pyrimidyl, pyridazyl, quinazolyl and quinoxalyl, where the rings can additionally be substituted by up to 2 radicals R4 [sic], andR2 [sic] is —(CH2)m—R8 [sic], where R8 [sic] can be phenyl, cyclohexyl- or indolyl and m=1 to 6, andX is a bond, —CH2—, —CH2CH2—, —CH═CH—, —C≡C—, —CONH—, —SO2NH— [sic], and and [sic]R1—X [sic] together are also  andR3 [sic] is hydrogen and CO—NR6R7 [sic],R4 [sic] is hydrogen, C1-C4-alkyl [sic], which is branched and unbranched, and —O—C1-C4-alkyl [sic];R5 [sic] is hydrogen, C1-C4-alkyl [sic], which is branched or unbranched, and —O—C1-C4-alkyl [sic];R6 [sic] is hydrogen, C1-C6-alkyl, which is branched and unbranched, andR7 [sic] is hydrogen, C1-C6-alkyl, which is branched or unbranched, andn is is [sic] a number 0, 1 or 2.