Compounds and methods to treat cardiac failure and other disorders
US6448257B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 24, 2000 |
| Grant date | Sep 10, 2002 |
| Priority date | — |
| Expiry date | Mar 24, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula: wherein the dotted line represents an optional bond;and the pharmaceutically acceptable salts thereof,wherein X1 is an alkyl bridge optionally containing an O, S, or N heteroatom that forms an aliphatic 5-7 membered ring and is optionally substituted by one or more of halo, OR, SR, NR2, RCO, COOR, CONR2, OOCR, or NROCR where R is H or alkyl (1-6C), or by one or more CN or═O, or by one or more aliphatic or aromatic 5- or 6-membered rings optionally containing 1-2 heteroatoms;R1 is  whereinX2 is CO or an isostere thereof;m is 0 or 1;Y is optionally substituted alkyl, optionally substituted aryl, or optionally substituted arylalkyl or two Y taken together may form an alkylene (2-3C) bridge;n is 0-4;Z1 is CH or N;X3 is CH or CHR where R is H or alkyl (1-6C), or an isostere thereof; andAr, R2 and R3 are as defined in the specification. These compounds are selective inhibitors of p38&agr; kinase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.