Glycoprotein IIb/IIIa antagonists

US6448269B1 · kind B1 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Matthew Joseph Fisher · Mooresville, US
• Anne Marie Happ · Indianapolis, US
• Joseph A. Jakubowski · Indianapolis, US
• Michael Dean Kinnick · Indianapolis, US
• Allen D. Kline · Bargersville, US
• Michael John Martinelli · Indianapolis, US
• John Michael Morin, Jr. · Brownsburg, US
• Michael Paal · Hamburg, DE
• Gerd Ruhter · Hamburg, DE
• Kenneth J. Ruterbories · Indianapolis, US
• Daniel Jon Sall · Greenwood, US
• Theo Schotten · Winsen (Luhe), DE
• Marshall A. Skelton · Indianapolis, US
• Wolfgang Stenzel · Reinbek, DE
• Robert Theodore Vasileff · Indianapolis, US

Key dates

• Filing date: Jun 18, 2001
• Grant date: Sep 10, 2002
• Expiry date: Jun 18, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.