Compounds useful as neuro-protective agents

US6448396B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Benjamin Alan Anderson · Zionsville, US
• Lawrence Joseph Heinz · Pittsboro, US
• Jill A. Panetta · Zionsville, US
• Michael LeRoy Phillips · Indianapolis, US
• John Allan Rieck, III · Indianapolis, US
• John Robert Rizzo · Indianapolis, US
• John Kevin Shadle · Fishers, US
• David Lee Varie · Indianapolis, US

Key dates

• Filing date: Sep 23, 1998
• Grant date: Sep 10, 2002
• Expiry date: Sep 23, 2018

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a process of preparing a compound of the formula IV wherein:R1 and R2 are each individually -(C1-C6)alkyl, -(C1-C6)alkoxy or phenyl,R3 is H or -(C1-C6)alkyl,R6 is —NR7R8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with -(C1-C4)alkyl or  and R7 and R8 are each individually hydrogen, -(C1-C6)alkyl, —(CH2)pOH,  —(CH2)p-piperidyl, —(CH2)pS(C1-C6)alkyl, —(CH2)pO(C1-C6)alkyl  where R9 is (C1-C6)alkyl;P is an integer from 1-3 both inclusive;q is 0 or 1; andt is 1 to 6 both inclusive;or a pharmaceutically acceptable salt, hydrate or optical isomer thereof, which is useful as a neuroprotective agent.