Process for water soluble azole compounds

US6448401B1 · kind B1 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Chung-Pin H. Chen · Madison, US
• Timothy P. Connolly · Portland, US
• Laxma Kolla · Princeton, US
• John D. Matiskella · Wallingford, US
• Richard H. Mueller · Marl, DE
• Yadagiri Pendri · Matawan, US
• Dejah T. Petsch · Mansfield Center, US

Key dates

• Filing date: Oct 16, 2001
• Grant date: Sep 10, 2002
• Expiry date: Oct 16, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6518
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is directed toward preparation of water-soluble triazole antifungal compounds are provided having the general formula wherein A is the non-hydroxy portion of a triazole antifungal compound of the type containing a secondary or tertiary hydroxyl group and R and R1 are as defined in the specification.