Method for retrovirus vector production by separated gag and pol expression
US6451304B1 · kind B1 · utility
12Cited by
1References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1999 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Mar 9, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16043
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a system for production of retroviruses which are replication incompetent. In the system, gag and pol retroviral structural proteins are expressed separately by different plasmids in a packaging cell line. Separate gag and pol expressing plasmids are provided, as are packaging cell lines containing such plasmids. Retrovirus products of the retroviral vector production system, including chimeric retroviruses, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.