Methods for therapy of neurodegenerative disease of the brain
US6451306B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 15, 1998 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Apr 15, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/021
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a specific protocol for use in grafting donor cells genetically modified to produce nerve growth factors into grafting sites within the cholinergic basal forebrain and is especially useful in treating neurodegenerative conditions such as Alzheimer's Disease. Grafting sites are selected for proximity to previously identified defective, diseased or damaged brain cells. Each graft is situated no more than about 550 &mgr;m from a targeted cell and no more than about 5 mm from another graft. Depending on the size of the region to be treated, the number of grafting sites will vary upwards of 10 sites, with between 5 and 10 sites serving to deliver a therapeutically significant dosage of nerve growth factors to targeted cells. Donor cells are delivered in a composition concentration of at least 1×105 cells/&mgr;l, wherein each graft is comprised of between 2 and 20 &mgr;l of the donor cell composition. The composition is delivered to each grafting site over a period of about 5-10 minutes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.