Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US6451346B1 · kind B1 · utility
133Cited by
8References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 23, 1998 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Dec 24, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to the development of pharmaceutical compositions which provide for sustained release of biologically active polypeptides. More specifically, the invention relates to the use of pH/thermosensitive biodegradable hydrogels, consisting of a A-B di block or A-B-A tri block copolymer of poly(d,l- or l-lactic acid) (PLA) or poly(lactide-co-glycolide) (PLGA) (block A) and polyethylene glycol (PEG) (block B), with ionizable functional groups on one or both ends of the polymer chains, for the sustained delivery of biologically active agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.