Detection of a leptin receptor variant and methods for regulating obesity
US6451523B1 · kind B1 · utility
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1References
19Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 18, 1996 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Jan 18, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a variant form of the receptor for the obese gene product. In particular, the invention relates to methods of detecting this receptor variant in cells and tissues of obese individuals. In addition, it relates to methods of inhibiting or down-regulating expression of this variant in cells to augment their responsiveness to weight regulation by leptin as well as methods of using compounds to directly activate signal transduction pathways associated with this ligand-receptor system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.