Thymidine kinase mutants
US6451571B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 17, 1999 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Mar 17, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution upstream from a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as compared to unmutated thymidine kinase. Within another aspect, one of the mutations is an amino acid substitution within a DRH nucleoside binding site which increases a biological activity of the thymidine kinase, as compared to unmutated thymidine kinase. Also provided are vectors suitable for expressing such DNA molecules, as well as methods for utilizing such vectors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.