Aggrecan degrading metallo proteases
US6451575B1 · kind B1 · utility
8Cited by
0References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 24, 1998 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Jul 24, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/102
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to the family of aggrecan degrading metallo proteases (ADMPs) that exhibit the ability to cleave the aggrecan core protein between amino acid residues Glu373-Ala374. The invention encompasses the nucleic acids encoding such enzymes, processes for production of recombinant ADMPs, compositions containing such enzymes, and the use of these enzymes in various assays and for the development of novel inhibitors for use as therapies for diseases involving aggrecanase-mediated degradation of cartilage or other aggrecanase-associated diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.