Recombinant adenovirus for tissue specific expression in heart
US6451594B1 · kind B1 · utility
17Cited by
5References
4Claims
0Family size
Assignee
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Key dates
| Filing date | Sep 10, 1999 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Sep 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a human type-5 recombinant adenovirus vector for achieving cardiac restricted transcription involving utilization of the cardiomyocyte-restricted cardiac ankyrin repeat protein (CARP) promoter with inclusion of the inverted terminal repeat sequences from human adeno-associated virus (AAV). Using green fluorescent protein (GFP) as a marker gene, the recombinant adenovirus vector (Ad/CG/ITR) is shown to direct transgene expression to myocardial tissue in vivo and in vitro in mouse models.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.