Noncleavable Fas ligand
US6451759B1 · kind B1 · utility
8Cited by
2References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1998 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Nov 26, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2035/126
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention generally provides polypeptides comprising a noncleavable form of a Fas ligand and having a capacity to activate a Fas receptor-mediated pathway involved in cell death, pharmaceutical compositions of such polypeptides, nucleic acids encoding such polypeptides, and cell lines capable of expressing these nucleic acids. Also provided are therapeutic and prophylactic methods of using such polypeptides, compositions, and cells lines for treating patients suffering from disorders resulting from dysregulation or inappropriate stimulation of the Fas receptor-mediated pathway.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.