Heterocyclic &bgr;-3 adrenergic receptor agonists

US6451814B1 · kind B1 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Mark Anthony Ashwell · Plainsboro, US
• William Ronald Solvibile · Monmouth Junction, US
• Dominick Anthony Quagliato · Edison, US
• Albert J. Molinari · Princeton, US

Key dates

• Filing date: Jul 12, 2001
• Grant date: Sep 17, 2002
• Expiry date: Jul 12, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds of Formula I having the structure U, V, W, X, and Y are as defined hereinbefore,or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.