Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives

US6451858B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Roger Fujimoto · Morristown, US
• Leslie Wighton McQuire · Hackettstown, US
• Benjamin Mugrage · Berkeley Heights, US
• John H. van Duzer · Phillipsburg, US

Key dates

• Filing date: Sep 13, 2001
• Grant date: Sep 17, 2002
• Expiry date: Sep 13, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are the compounds of formula I wherein R is methyl or ethyl; R1 is chloro or fluoro; R2 is hydrogen or fluoro; R3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or hydroxy; R4 is hydrogen or fluoro; and R5 is chloro, fluoro, trifluoromethyl or methyl; and pharmaceutically acceptable salts thereof, as selective COX-2 cyclooxygenase inhibitors; and pharmaceutically acceptable prodrug esters thereof.