Peptide derivatives
US6451970B1 · kind B1 · utility
22Cited by
6References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 20, 1997 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Feb 20, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P5/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to derivatives of insulin and insulin analogues wherein the N-terminal amino group of the B-chain and/or the &egr;-amino group of Lys in position B28, B29 or B30 has a substituent of the formula —CO—W—COOH wherein W is a divalent long chain hydrocarbon group having from 12 to 22 carbon atoms and zinc complexes thereof are soluble at physiological pH values and exhibit a long disappearance half-life from the injection site after subcutaneous injection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.