Bi-or multifunctional molecules based on a dendroaspin scaffold
US6451976B1 · kind B1 · utility
8Cited by
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40Claims
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Key dates
| Filing date | Sep 20, 1999 |
| Grant date | Sep 17, 2002 |
| Priority date | — |
| Expiry date | Sep 20, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Dendroaspin, a polypeptide neurotoxin analogue is modified by recombinant DNA techniques, particularly “loop grafting” to provide a modified polypeptide. The modified polypeptide is constructed so as to retain dendroaspin activity, for example, platelet adhesion to fibrinogen, in addition to possessing one or more further biological or biochemical activities not native to dendroaspin, for example, platelet derived growth factor (PDGF) activity or hirudin activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.