Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5

US6451982B1 · kind B1 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Chuan-Chu Chou · Westfield, US
• Nicholas J. Murgolo · Millington, US
• John S. Abrams · Belmont, US
• Chung-Her Jenh · Edison, US
• Mary E. Petro · Green Pond, US
• Jon Silver · San Jose, US
• Stephen Tindall · Madison, US
• William T. Windsor · East Brunswick Township, US
• Paul J. Zavodny · Mountainside, US

Key dates

• Filing date: Mar 28, 2000
• Grant date: Sep 17, 2002
• Expiry date: Mar 28, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.