Composites for tissue regeneration and methods of manufacture thereof
US6454811B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 12, 1999 |
| Grant date | Sep 24, 2002 |
| Priority date | — |
| Expiry date | Oct 12, 2019 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB33Y80/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Composite devices for tissue engineering are provided having a gradient of one or more of the following: materials, macroarchitecture, microarchitecture, or mechanical properties, which can be used to select or promote attachment of specific cell types on and in the devices prior to and/or after implantation. In various embodiments, the gradient forms a transition zone in the device from a region composed of materials or having properties best suited for one type of tissue to a region composed of materials or having properties suited for a different type of tissue. The devices are made in a continuous process that imparts structural integrity as well as a unique gradient of materials in the architecture. The gradient may relate to the materials, the macroarchitecture, the microarchitecture, the mechanical properties of the device, or several of these together. The devices disclosed herein typically are made using solid free form processes, especially three-dimensional printing process (3DP™). The device can be manufactured in a single continuous process such that the transition from one form of tissue regeneration scaffold and the other form of tissue regeneration scaffold ha…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.