Metabolically engineered E. coli for enhanced production of oxaloacetate-derived biochemicals
US6455284B1 · kind B1 · utility
100Cited by
6References
10Claims
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Key dates
| Filing date | Oct 13, 1999 |
| Grant date | Sep 24, 2002 |
| Priority date | — |
| Expiry date | Oct 13, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y604/01001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Metabolic engineering is used to increase the carbon flow toward oxaloacetate to enhance production of bulk biochemicals, such as lysine and succinate, in bacterial fermentations. Carbon flow is redirected by genetically engineering the cells to overexpress the enzyme pyruvate carboxylase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.