Alternatively targeted adenovirus
US6455314B1 · kind B1 · utility
30Cited by
25References
60Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1999 |
| Grant date | Sep 24, 2002 |
| Priority date | — |
| Expiry date | Sep 10, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a recombinant protein having an amino terminus of an adenoviral fiber protein and having a trimerization domain. A fiber incorporating such a protein exhibits reduced affinity for a native substrate than does a wild-type adenoviral fiber trimer. The present invention further provides an adenovirus incorporating the recombinant protein of the present invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.