Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents
US6455495B1 · kind B1 · utility
35Cited by
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29Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 14, 1999 |
| Grant date | Sep 24, 2002 |
| Priority date | — |
| Expiry date | Dec 14, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/645
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides conjugates of negatively charged peptide oligomers with therapeutic agents, moieties capable of recruiting endogenous bone-affecting agents, or imaging agents, useful for delivering the agents to bone tissue or calcified masses, and the methods of use thereof. The negatively charged peptide oligomers bind strongly but reversibly to bone tissue and calcified masses with a controllable affinity and retention time on the tissue or mass.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.