Cyclic sulfonamide derivatives as metalloproteinase inhibitors

US6455522B1 · kind B1 · utility

Assignee

• Bristol-Myers Squibb Pharma Company · US

Inventors

• Jingwu Duan · Yardley, US
• Lihua Chen · Boothwyn, US
• Robert J. Cherney · Newark, US
• Carl P. Decicco · New Hope, US
• Matthew E. Voss · Singapore, SG

Key dates

• Filing date: Feb 10, 1999
• Grant date: Sep 24, 2002
• Expiry date: Feb 10, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein rings ring B is a 4-8 membered cyclic sulfonamide containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.