Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

US6455534B2 · kind B2 · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Alexander James Bridges · Saline, US
• William Alexander Denny · Beachlands, NZ
• David Fry · Ypsilanti, US
• Alan Kraker · Ann Arbor, US
• Robert Frederick Meyer · Ann Arbor, US
• Gordon William Rewcastle · Drury, NZ
• Andrew Thompson

Key dates

• Filing date: Apr 2, 2001
• Grant date: Sep 24, 2002
• Expiry date: Apr 2, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: where:one of A or E is nitrogen, with remaining atoms carbon;X=O, S, NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms). Other terms are described in the specification.