Polypyrrolinone based inhibitors of matrix metalloproteases

US6455570B1 · kind B1 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Amos B. Smith, III · Yeadon, US
• Ralph F. Hirschmann · La Cañada Flintridge, US
• Thomas Nittoli · Pearl River, US
• Paul A. Sprengeler · San Diego, US

Key dates

• Filing date: Oct 9, 2001
• Grant date: Sep 24, 2002
• Expiry date: Oct 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/36
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of the formula wherein: R1, R2, R3, R4, R5, R6 are as defined herein, useful for the inhibition of inhibition of matrix metalloproteases (MMPs)and for treating conditions mediated by elevated levels of MMPs such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, gingivitis, solid tumor growth and tumor invasion by secondary metastasis, corneal ulceration, dermal ulceration, epidermolysis bullosa, neural degeneration, multiple sclerosis and surgical wound healing.