Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
US6455676B1 · kind B1 · utility
50Cited by
13References
12Claims
0Family size
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Key dates
| Filing date | Apr 25, 2000 |
| Grant date | Sep 24, 2002 |
| Priority date | — |
| Expiry date | Apr 25, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.