Chemokine &bgr;-4 polypeptides
US6458349B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 3, 1999 |
| Grant date | Oct 1, 2002 |
| Priority date | — |
| Expiry date | Mar 3, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.