Retro-inverso neurotrophic and analgesic peptides
US6458357B1 · kind B1 · utility
2Cited by
12References
28Claims
0Family size
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Key dates
| Filing date | Sep 3, 1998 |
| Grant date | Oct 1, 2002 |
| Priority date | — |
| Expiry date | Sep 3, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Retro-inverso peptide analogs derived from the active neurotrophic region of saposin C. The saposin C-derived peptides (prosaptides) induce neurite outgrowth in vitro, prevent programmed cell death, induce myelination and have an analgesic effect. They are useful in the treatment of central and peripheral nervous system disorders and pain management. The retro-inverso peptides are significantly more resistant to metabolic degradation than the corresponding non-inverted peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.